F22. UPREGULATING A REDUCED POPULATION OF PREFRONTAL PARVALBUMIN INTERNEURONS TO RESTORE COGNITIVE FUNCTION IN SCHIZOPHRENIA
نویسندگان
چکیده
منابع مشابه
Cortical parvalbumin interneurons and cognitive dysfunction in schizophrenia.
Deficits in cognitive control, a core disturbance of schizophrenia, appear to emerge from impaired prefrontal gamma oscillations. Cortical gamma oscillations require strong inhibitory inputs to pyramidal neurons from the parvalbumin basket cell (PVBC) class of GABAergic neurons. Recent findings indicate that schizophrenia is associated with multiple pre- and postsynaptic abnormalities in PVBCs,...
متن کاملPM509. Homeostatic synaptic plasticity of parvalbumin-positive inhibitory interneurons confers cognitive dysfunction in medial prefrontal cortex.
s | 85 Sub Topic(by disorder): [Attention deficit / Dimentia / Schizophrenia / (others)] Sub Topic(by methodology): [Neurophysiology / Computational Neuroscience / (others)] PM509 Homeostatic synaptic plasticity of parvalbuminpositive inhibitory interneurons confers cognitive dysfunction in medial prefrontal cortex. Jae Jin Shin1,2, Yong Gyu Kim2,3, Soo Yong Kim2,3, Joo Min Park4, and Sang Jeon...
متن کاملParvalbumin-positive basket interneurons in monkey and rat prefrontal cortex.
Differences in the developmental origin and relative proportions of biochemically distinct classes of cortical neurons have been found between rodents and primates. In addition, species differences in the properties of certain cell types, such as neurogliaform cells, have also been reported. Consequently, in this study we compared the anatomical and physiological properties of parvalbumin (PV)-...
متن کاملParvalbumin-positive interneurons of the prefrontal cortex support working memory and cognitive flexibility
Dysfunction of parvalbumin (PV)-positive GABAergic interneurons (PVIs) within the prefrontal cortex (PFC) has been implicated in schizophrenia pathology. It is however unclear, how impaired signaling of these neurons may contribute to PFC dysfunction. To identify how PVIs contribute to PFC-dependent behaviors we inactivated PVIs in the PFC in mice using region- and cell-type-selective expressio...
متن کاملDepression of excitatory synapses onto parvalbumin interneurons in the medial prefrontal cortex in susceptibility to stress.
In response to extreme stress, individuals either show resilience or succumb to despair. The prefrontal cortex (PFC) is required for coping with stress, and PFC dysfunction has been implicated in stress-related mental disorders, including depression. Nevertheless, the mechanisms by which the PFC participates in stress responses remain unclear. Here, we investigate the role of parvalbumin (PV) i...
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ژورنال
عنوان ژورنال: Schizophrenia Bulletin
سال: 2019
ISSN: 0586-7614,1745-1701
DOI: 10.1093/schbul/sbz018.434